Preheat the oven: Set to 375°F (190°C).
Grease a 9x13-inch baking dish.
Cook the pasta: Boil in salted water until just al dente (about 1–2 minutes less than package time). Drain and set aside.
Make the roux: In a large pot, melt butter over medium heat. Whisk in flour and cook 1–2 minutes until foamy and lightly golden.
Add the milk: Slowly whisk in warm milk.
Simmer, whisking, until slightly thickened and smooth, 3–5 minutes.
Season and cheese it: Stir in garlic powder, onion powder, mustard powder, paprika, salt, and pepper. Remove from heat. Fold in cheddar, mozzarella, and half the Parmesan until melted.
Combine with pasta: Add drained macaroni to the cheese sauce.
Stir to coat every noodle.
Assemble: Pour into the baking dish. Mix breadcrumbs with olive oil and the remaining Parmesan. Sprinkle evenly over the top.
Bake: Bake 18–22 minutes until bubbling at the edges and lightly browned on top.
For extra color, broil 1–2 minutes, watching closely.
Rest and serve: Let it sit 5–10 minutes so the sauce settles. Scoop and enjoy that cheesy pull.